prognosis of proximal upper-third gastrsic cancer excluding tumors originating in the esophgogastric junction

Abstract

Purpose: The objective of the current study was to compare surgical outcomes and prognosis based on the longitudinal location of stomach tumors in patients undergoing curative treatment. The specific focus was on the prognosis for adenocarcinomas in the proximal upper-third of the stomach, excluding tumors in the esophagogastric junction (EGJ).

Methods: Data from patients who underwent curative treatment for gastric adenocarcinoma between 2000 and 2010 at a single institution were analyzed retrospectively. Excluding tumors of EGJ origin, data from 797 patients were reviewed?686 with distal gastric cancer and 111 with proximal gastric cancer. Clinicopathology features, tumor stage, surgical outcomes, recurrence, and survival were compared between the groups.

Results: Gastric cancer recurred in 136 of the patients (17.1%). Although differences were detected between proximal and distal cancer patients in the prevalence in males versus females (74.8% vs. 63.4%, P=0.020) and in undifferentiated histology (60.4% vs. 47.7%, P=0.013), the prognosis for proximal gastric cancer did not differ from distal gastric cancer. The overall 5-year disease-free survival rate was 84.9% and 81.4% in proximal and distal cancer patients, respectively (P=0.389).

Conclusion: The prognosis of proximal cancer, excluding tumors of EGJ origin, did not differ from the prognosis of more distal gastric cancer. Clarifying the prognosis of proximal gastric cancer will require the large-scale comparison of an organized, multi-institution database.