Purpose: To report the first case of a 53-year-old male patient diagnosed with central Horner syndrome, associated vertebral artery dissection, which has never been reported in Korea to date.Case summary: A presented conjunctival hyperemia left eye for over 4 months, past history acute subarachnoid hemorrhage and ruptured dissecting aneurysm artery. On slit-lamp examination, mild ptosis upper eyelid were noted his eye. The pupil was smaller than right without afferent pupillary defects either Anisocoria greater dark, dilation lag pupil. systemic he complained numbness lower extremities symptoms leaning when walking. After instillation 0.5% apraclonidine, anisocoria reversed, disappeared. Magnetic resonance images revealed chronic infarction lateral medulla, syndrome Wallenberg syndrome.Conclusions: We present medullary caused by dissection.