지역사회 연관 Clostridioides difficile 감염의 임상적, 미생물학적 위험인자

Abstract

Background: The incidence of community-associated (CA) Clostridioides difficile infection(CDI) has increased in Korea. In this study, we evaluated CA-CDI risk factors in terms of clinicalfeatures and ribotype considering its region-specific molecular epidemiology. Methods: A retrospective case-control study was performed on two groups of CDI patients:127 subjects with CA-CDI and 265 subjects with healthcare-associated (HA)-CDI. Risk factorsfor CA-CDI were evaluated in terms of clinical and microbiological features such as toxin typeand ribotype. Results: A comparison of the two groups of CDI patients revealed that inflammatory boweldisease, diarrhea, abdominal pain, and fever were more closely associated with CA-CDI. Thetoxin types and ribotypes of C. difficile were similar between the two groups. After adjustingfor variables, no risk factors were identified for CA-CDI compared with HA-CDI. Conclusion: Specific risk factors for CA-CDI were not identified in this study.