Bromocriptine을 이용한 진행성 핵상마비 유사 증후군의 치료:증례보고

Abstract

Progressive supranuclear palsy (PSP)-like syndrome is a condition that mimics the neurological features of PSP, which is characterized by supranuclear vertical gaze palsy, cognitive decline, and postural instability. The syndrome is a reversible condition that can occur secondary to other diseases or drug regimens, while PSP is a non-reversible neurodegenerative disease. We present three patients who developed PSP-like syndrome after hydrocephalus following intraventricular hemorrhage. The patients showed symptoms of PSP and imaging findings known as the “hummingbird” sign. Bromocriptine alleviated the symptoms of the PSP-like syndrome, while levodopa had little effect. Midbrain atrophy with hydrocephalus after intraventricular hemorrhage may cause clinically and radiologically similar characteristics to PSP. Bromocriptine improved the physical function of the PSP-like syndrome, except for vertical gaze palsy. The pharmacodynamic pathway may have led to this result. Identifying the underlying medical disorder may lead to accurate diagnosis for geriatric patients with PSP-like syndrome.